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13th november 2012
Maison de la Chimie, Paris
Characterisation and targeting of breast cancer stem cells
Daniel BIRNBAUM
Inserm - Université de la Méditerranée - Institut Paoli Calmette, Marseille
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Characterisation and targeting of breast cancer stem cells
BCSC
BCSCs can be isolated using:
Breast cancer is a public health problem
Breast CSCs resist to conventional therapies
To eradicate cancer anti-CSC therapies are needed
Targets for anti-CSC therapies can be found in studying:
Xenograft model to find targets
1. New targets in CSC pathways
New targets in CSC pathways: IL8/IL8R pathway
Discovery of CSC pathways: Mevalonate pathway
Discovery of CSC pathways: new genes
To go further: high throughput RNAi screen
2. New targets in CSC regulatory programs
Epigenetic control and differentiation therapy of breast cancer: HDAC inhibitor as an example
3. New targets in genomic alterations
Genomic of molecular subtypes
Genomic of luminal B breast cancers
Identification of ZNF703 as a new (luminal B) breast cancer oncogene
Gene alterations in luminal B are both common and specific
Alterations in molecular subtypes
Breast CSCs generate relapse and metastasis
Four approaches to study metastasis
Xenograft model for metastasis
Conclusions and Perspectives
Thanks
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