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13th november 2012
Maison de la Chimie, Paris
Epigenetic control of T cell plasticity
Sebastian AMIGORENA
CNRS Inserm - Institut Curie, Paris
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Epigenetic control of T cell plasticity
T helper (Th) cell differentiation results in effective immune responses to different pathogens or pathologies
T cell differentiation, commitment...
T cell differentiation, commitment and silencing
Epigenetic silencing: the heterochromatin protein 1 (HP1) pathway
Suv39h1 and HP1a inhibition skew lineage commitment toward Th1 differentiation in vitro
Suv39h1 and HP1a inhibition skew lineage commitment toward Th1 differentiation in vivo
Model for the control of Th2-to-Th1 plasticity by Suv39h1 and HP1a
Spontaneous tumor antigen model for testing of epigenetic drugs
Conclusion and perspectives:
Acknowledgments
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